The most important and interesting aspect of the kratom tree leaf, are the active alkaloids that are contained within. The kratom leaf will actually vary in its alkaloid profile depending on the age, geographic location, month to month, and time of harvest. This has lead teams that researched kratom (Shellerad et al. in the 1970’s) to conclude that their may be different geographical variants within the same species.
(Raubasine), a cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer
, an opioid antagonist
a calcium channel blocker
Dopamine mediating anti-locomotives
an antioxidant, antiaggregant, antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor
a partial opioid agonist
an analgesic, antitussive, antidiarrheal, primary psychoactive in kratom
an immunostimulant, anti-leukemic
an immunostimulant
an analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist
a vasodilator, antihypertensive, muscle relaxer, diuretic, anti-amnesic, possible immunostimulant
a smooth muscle relaxer
a vasodilator, antihypertensive, calcium channel blocker, antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic
a weaker opioid agonist
a more smooth muscle relaxer
an anti-leukemic;
a hypoglycemic, anti-adrenergic (at alpha-2