The most important and interesting aspect of the kratom tree leaf, are the active alkaloids that are contained within. The kratom leaf will actually vary in its alkaloid profile depending on the age, geographic location, month to month, and time of harvest. This has lead teams that researched kratom (Shellerad et al. in the 1970’s) to conclude that their may be different geographical variants within the same species.

Ajmalicine (Raubasine), a cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer

Corynantheidine, an opioid antagonist

Corynoxeine, a calcium channel blocker

Corynoxine A and B, Dopamine mediating anti-locomotives

Epicatechin, an antioxidant, antiaggregant, antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor

9-Hydroxycorynantheidine, a partial opioid agonist

7-Hydroxymitragynine, an analgesic, antitussive, antidiarrheal, primary psychoactive in kratom

Isomitraphylline, an immunostimulant, anti-leukemic

Isopteropodine, an immunostimulant

Mitragynine, an analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist

Mitraphylline, a vasodilator, antihypertensive, muscle relaxer, diuretic, anti-amnesic, possible immunostimulant

Paynantheine, a smooth muscle relaxer

Rhynchophylline, a vasodilator, antihypertensive, calcium channel blocker, antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic

Speciociliatine, a weaker opioid agonist

Speciogynine, a more smooth muscle relaxer

Speciophylline, an anti-leukemic;

Tetrahydroalstonine, a hypoglycemic, anti-adrenergic

One Response

  1. The health benefits of kratom include ability to relieve pain, boost energy, boost metabolism, increase sexual energy, improve the immune system, prevent diabetes. Kratom is a native plant from Southeast Asia regions like Thailand, Indonesia, Malaysia, and Vietnam. Mostly this tree is used for preparing medicines as it has the multitude of health benefits.

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