The most important and interesting aspect of the kratom tree leaf, are the active alkaloids that are contained within. The kratom leaf will actually vary in its alkaloid profile depending on the age, geographic location, month to month, and time of harvest. This has lead teams that researched kratom (Shellerad et al. in the 1970’s) to conclude that their may be different geographical variants within the same species.

Ajmalicine (Raubasine), a cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer

Corynantheidine, an opioid antagonist

Corynoxeine, a calcium channel blocker

Corynoxine A and B, Dopamine mediating anti-locomotives

Epicatechin, an antioxidant, antiaggregant, antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor

9-Hydroxycorynantheidine, a partial opioid agonist

7-Hydroxymitragynine, an analgesic, antitussive, antidiarrheal, primary psychoactive in kratom

Isomitraphylline, an immunostimulant, anti-leukemic

Isopteropodine, an immunostimulant

Mitragynine, an analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist

Mitraphylline, a vasodilator, antihypertensive, muscle relaxer, diuretic, anti-amnesic, possible immunostimulant

Paynantheine, a smooth muscle relaxer

Rhynchophylline, a vasodilator, antihypertensive, calcium channel blocker, antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic

Speciociliatine, a weaker opioid agonist

Speciogynine, a more smooth muscle relaxer

Speciophylline, an anti-leukemic;

Tetrahydroalstonine, a hypoglycemic, anti-adrenergic