The most important and interesting aspect of the kratom tree leaf, are the active alkaloids that are contained within. The kratom leaf will actually vary in its alkaloid profile depending on the age, geographic location, month to month, and time of harvest. This has lead teams that researched kratom (Shellerad et al. in the 1970’s) to conclude that their may be different geographical variants within the same species.
Ajmalicine (Raubasine), a cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer
Corynantheidine, an opioid antagonist
Corynoxeine, a calcium channel blocker
Corynoxine A and B, Dopamine mediating anti-locomotives
Epicatechin, an antioxidant, antiaggregant, antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor
9-Hydroxycorynantheidine, a partial opioid agonist
7-Hydroxymitragynine, an analgesic, antitussive, antidiarrheal, primary psychoactive in kratom
Isomitraphylline, an immunostimulant, anti-leukemic
Isopteropodine, an immunostimulant
Mitragynine, an analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist
Mitraphylline, a vasodilator, antihypertensive, muscle relaxer, diuretic, anti-amnesic, possible immunostimulant
Paynantheine, a smooth muscle relaxer
Rhynchophylline, a vasodilator, antihypertensive, calcium channel blocker, antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic
Speciociliatine, a weaker opioid agonist
Speciogynine, a more smooth muscle relaxer
Speciophylline, an anti-leukemic;
Tetrahydroalstonine, a hypoglycemic, anti-adrenergic